Searchable abstracts of presentations at key conferences in endocrinology

ea0090p658 | Endocrine-related Cancer | ECE2023

Cellular models of parathyroid carcinoma: preliminary results

Palmini Gaia , Marini Francesca , Giusti Francesca , Donati Simone , Aurilia Cinzia , Falsetti Irene , Zonefrati Roberto , Perigli Giuliano , Santoro Roberto , Nesi Gabriella , Luisa Brandi Maria

Parathyroid carcinoma (PC) is an extremely rare endocrine malignancy of the parathyroid glands, representing less than 1% of all parathyroid neoplasms. PC is characterized by an excessive secretion of parathyroid hormone (PTH) and severe hypercalcemia. In contrast to parathyroid adenoma, the prognosis for patients with PC is poor, with an overall survival rate of 78-85% and 49-70% respectively at 5 and 10 years after diagnosis, due to the commonly unmanageable hypercalcaemia, ...